The rate of primary hypothyroidism in diabetic patients is greater than in the non-diabetic population. An observational study
La proporción de hipotiroidismo primario en pacientes diabéticos es mayor que la de pacientes no diabéticos. Estudio observacional
a Subdirección de Investigación, Facultad de Medicina U.A.N.L., Monterrey, NL, Mexico
b Departamento de Medicina Interna, Clínica Nova, Monterrey, NL, Mexico
KeywordsType 2 diabetes mellitus. Primary hypothyroidism. Cardiovascular risk.
Palabras ClaveDiabetes mellitus tipo 2. Hipotiroidismo primario. Riesgo cardiovascular.
ResumenBackground and objective
The aim of our study was to identify the rate of diabetic patients treated for hypothyroidism and compare them with a group without type 2 diabetes mellitus (T2DM).Patients and methods
We reviewed the computerized clinical records of 5161 patients. We identified diabetic patients treated with l -thyroxine. We compared the prevalence of PH with those patients under treatment with levothyroxine without T2DM. We excluded patients with a thyroid neoplasia, thyroid surgery, panhypopituitarism, or surgical complications of multinodular goiter or a thyroid nodule. Subclinical hypothyroidism was not considered.Results
We included 1848 adult patients with T2DM in the study group, 58% women and 42% men. For the control group, we included 3313 non-diabetic patients, 55% women and 45% men. The mean age in the study group was 52±7 years, and 47±4 years in the control group (p<.001). The rate of hypothyroidism in the study group was 5.7%, and in the control group 1.8% (odds ratio of 3.45; 95% confidence interval 2.51–4.79) (p<.001).Conclusion
A strong association between T2DM and hypothyroidism was found. We recommend a thyroid profile in all patients with T2DM, similar to the recommendation in type 1 diabetes mellitus.